Donald F. Klein, MD DSc

Donald F. Klein

Senior Scientific Advisor
Child Mind Institute

Donald Klein, MD, DSc, has been a dominant figure in the field of treatment science and a prime mover in the improvement of diagnosis and our understanding of psychiatric illness for over half a century. His pioneering work applying both psychological and pharmaceutical approaches to therapy has become standard procedure in the treatment of psychiatric disorders and chronic emotional distress. Dr. Klein is Professor Emeritus in the Department of Psychiatry at Columbia University College of Physicians and Surgeons, former director of research at the New York State Psychiatric Institute, a research psychiatrist at the Nathan Kline Institute of Psychiatric Research, and a Senior Scientific Advisor at the Child Mind Institute. 

As Senior Scientific Advisor at the Child Mind Institute, Dr. Klein works with Michael P. Milham, MD, PhD, the Director of the Center for the Developing Brain on establishing a research strategic plan. Dr. Klein also works with Child Mind Institute clinicians to evaluate the effectiveness of their new and innovative treatments and ability to take them to a national scale.   

Dr. Klein entered medical training in 1952 with the intention of becoming a psychoanalyst, but soon became particularly interested in the burgeoning field of psychopharmacology. This interest bloomed into an influential clinical and research career that has shaped our understanding and treatment of childhood anxiety and hyperactivity (ADHD), adult and childhood asocial schizophrenia, unipolar and bipolar depression, and social phobia. Dr. Klein's 1960 discovery that the drug imipramine had an anti-panic effect not only led to helpful treatments—it eventually defined a disorder and introduced the concept of the biological bases of psychiatric illness.

Dr. Klein was a leading contributor to the third addition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III) in 1980, which ushered in the age of modern psychiatry. He co-authored the first textbook of clinical psychopharmacology, Diagnosis and Drug Treatment in Psychiatric Disorders. His many editorial assignments include extensive experience with the Archives of General Psychiatry, and he has sat on the editorial board of 10 peer review journals. Dr. Klein has also made informing the general public of advances in psychiatric treatment one of his priorities. Of his 19 books, two are specifically aimed at educating readers about biopsychiatry, psychotherapy, and depression: Mind, Mood and Medicine: A Guide to the New Biopsychiatry and Understanding Depression.

Please help us improve the Symptom Checker!

Click here to share your thoughts about using the tool.